Mechanisms+of+Unconsiousness

General Anesthesia
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 * Drug induced reversible depression of the central nervous system.
 * Goal of General Anesthesia is fourfold:
 * 1) Unconsciousness
 * 2) Amnesia
 * 3) Analgesia
 * 4) Akinesia
 * Measurement of Anesthesia is defined as MAC (Minimum Alveolar Concentration) where 50% of humans don’t respond to surgical incision.

Where do General Anesthetics work?

 * Brainstem
 * Reticular Formation in pons (Locus Coeruleus) which with thalamus and
 * Hypothalamus control the sleep /wake cycle
 * Thalamus
 * Basal Ganglia
 * Thalamus- Cortex Circuit
 * Involvement in Burst Suppression
 * <span style="font-family: Arial,Helvetica,sans-serif;">Cerebral Cortex
 * <span style="font-family: Arial,Helvetica,sans-serif;">Complex integration - Memory and awareness affected

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